Specific and Randomly Derived Immunoactive Peptide Mimotopes of Mycobacterial Antigens

Chitinases and Peptide Mimotopes

high-affinity chitin binding region [4]. Five homologs of the plant chitinases have been identified in A. fumiga-tus. Only one member of this family has a putative GPI anchor and associated cleavage site (http://www.tigr. org/tdb/e2k1/afu1/), suggesting that this enzyme may Inhibition of glycosylhydrolases by peptides mimick-function in morphogenesis since most of the GPI an-ing carbohydrates o...

A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens

The heat shock protein, Hsp70, has been shown to play an important role in tumour immunity. Vaccination with Hsp70-peptide complexes (Hsp70-PCs), isolated from autologous tumour cells, can induce protective immune responses. We have developed a novel method to identify synthetic mimic peptides of Hsp70-PCs and to test their ability to activate T-cells. Peptides (referred to as "recognisers") th...

Specific recognition of mycobacterial protein and peptide antigens by γδ T cell subsets following infection with virulent Mycobacterium bovis.

Promoting effective immunity to Mycobacterium bovis infection is a challenge that is of interest to the fields of human and animal medicine alike. We report that γδ T cells from virulent M. bovis-infected cattle respond specifically and directly to complex, protein, and nonprotein mycobacterial Ags. Importantly, to our knowledge, we demonstrate for the first time that bovine γδ T cells specific...

Specific Recognition of Mycobacterial Protein and Peptide Antigens by gd T Cell Subsets following Infection with Virulent Mycobacterium bovis

Monoclonal antibodies specific for Neisseria meningitidis group B polysaccharide and their peptide mimotopes.

From five mice immunized with Escherichia coli K1 bacteria, we produced 12 immunoglobulin M hybridomas secreting monoclonal antibodies (MAbs) that bind to Neisseria meningitidis group B (NMGB). The 12 MAbs also bound the capsular polysaccharide (PS) of E. coli K1 [which, like NMGB, is alpha(2-8)-linked polysialic acid (PSA)] and bound to EV36, a nonpathogenic E. coli K-12 strain producing alpha...